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Pancreatic insufficiency is not a prevalent problem in Alagille syndrome.

Kamath BM, Piccoli DA, Magee JC, Sokol RJ, Childhood Liver Disease Research and Education Network. Pancreatic insufficiency is not a prevalent problem in Alagille syndrome. J Pediatr Gastroenterol Nutr 2012 Nov;55(5):612-4.

PubMed ID: 22614108
Public Release Type: Journal
Publication Year: 2012
Affiliation: Hospital for Sick Children, Toronto, Canada. binita.kamath@sickkids.ca
DOI: https://doi.org/10.1097/MPG.0b013e31825eff61
Authors: Piccoli DA, Childhood Liver Disease Research and Education Network, Sokol RJ, Magee JC, Kamath BM
Studies: A Prospective Database of Infants With Cholestasis , Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis

Abstract

Alagille syndrome (ALGS) is an inherited multisystem disorder in which pancreatic insufficiency (PI) has been regarded a minor but important clinical manifestation. As part of a multicenter prospective study, 42 patients with ALGS underwent fecal elastase (FE) measurement to screen for exocrine PI. FE measurements were normal (>200 μg/g) in 40 (95%) and indeterminate (100-200 μg/g) in 2 (5%). As FE is the most reliable screen for PI, these data suggest that PI is not a prevalent problem in ALGS.

Home chevron_right Publications chevron_right Pancreatic insufficiency is not a prevalent problem in Alagille syndrome.

Pancreatic insufficiency is not a prevalent problem in Alagille syndrome.

Kamath BM, Piccoli DA, Magee JC, Sokol RJ, Childhood Liver Disease Research and Education Network. Pancreatic insufficiency is not a prevalent problem in Alagille syndrome. J Pediatr Gastroenterol Nutr 2012 Nov;55(5):612-4.

Abstract