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Publication Information
Public Release Type
Journal
Publication Year
2012
Authors
Brunt EM, Kleiner DE, Neuschwander-Tetri BA, Tonascia J, Unalp A, Wilson L
Studies
Citation
Brunt EM, Kleiner DE, Wilson L, Unalp A, Tonascia J, Neuschwander-Tetri BA. Histologic Predictors of Improvement in Fibrosis in NASH: Results from the Clinical Research Network PIVENS Trial. Hepatology 2012 Oct;56(Supplement S1):887A.Abstract
The primary response in the Pioglitazone v Vitamin
E v Placebo for the Treatment of Nondiabetic Patients with
Nonalcoholic Steatohepatitis (PIVENS) trial (NEJM
2010;18:1675) was histologic and defined as decrease in the
nonalcoholic fatty liver disease activity score (NAS) =/>2 with
at least one point contribution from hepatocellular ballooning
and no worsening of fibrosis stage.