NIDDK Central Repository - Histologic Predictors of Improvement in Fibrosis in NASH: Results from the Clinical Research Network PIVENS Trial

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NIDDK Central Repository

Publication Information

Public Release Type

Journal

Publication Year

2012

Authors

Brunt EM, Kleiner DE, Neuschwander-Tetri BA, Tonascia J, Unalp A, Wilson L

Studies

PIVENS

Citation

Brunt EM, Kleiner DE, Wilson L, Unalp A, Tonascia J, Neuschwander-Tetri BA. Histologic Predictors of Improvement in Fibrosis in NASH: Results from the Clinical Research Network PIVENS Trial. Hepatology 2012 Oct;56(Supplement S1):887A.

Abstract

The primary response in the Pioglitazone v Vitamin E v Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis (PIVENS) trial (NEJM 2010;18:1675) was histologic and defined as decrease in the nonalcoholic fatty liver disease activity score (NAS) =/>2 with at least one point contribution from hepatocellular ballooning and no worsening of fibrosis stage.