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Publication Information
Affiliation
Division of Gastroenterology, Department of Medicine, and Preventive Medicine, University of California San Diego, La Jolla, CA 92093, USA. roloomba@ucsd.edu
Authors
Abdelmalek MF, Abraham M, Ackermann S, Aouizerat B, Bambha K, Bass M, Bass NM, Behling C, Belt P, Boyett S, Brancati FL, Brandt P, Bringman D, Brunt EM, Buie S, Chalasani N, Clark JM, Collins J, Colvin R, Contos MJ, Cummings OW, Dasarathy J, Dasarathy S, Diehl AM, Donithan M, Doo E, Doo EC, Durelle J, Ferrell LD, Fuchs M, Ghabril M, Gottfried M, Green M, Gu B, Guy C, Hameed B, Hanna M, Hassanein T, Hawkins C, Hollick R, Hoofnagle JH, Isaacson M, Jin WK, Jones A, Kigongo C, Killenberg P, King D, Kleiner DE, Klipsch A, Kowdley KV, Kwan S, Lavine J, Lavine JE, Liu YC, Loomba R, Luketic VA, Lydecker A, Mann P, May KP, McCullough AJ, Merriman R, Miriel L, Mooney J, Morgan A, Morris A, Nelson J, Neuschwander-Tetri BA, Nguyen A, Noble K, Nonalcoholic Steatohepatitis Clinical Research Network, Pabst M, Pagadala M, Pan YP, Park J, Patton H, Pierce T, Piercy D, Puri P, Ragozzino L, Robuck PR, Rogers N, Rosenthal M, Sandhu B, Sanyal AJ, Sargeant C, Sargent R, Shaw C, Sherker A, Siegner J, Sirlin C, Smith M, Srivastava S, Stead A, Steel T, Sternberg A, Stewart S, Subbarao G, Tandra S, Thompson J, Tonascia J, Unalp A, Ünalp-Arida A, Van Natta M, Vaughn I, Vuppalanchi R, Wang C, White M, Wilson L, Yates K, Yeh M, Yerian L, Zein C
Citation
Loomba R, Abraham M, Unalp A, Wilson L, Lavine J, Doo E, Bass NM, Nonalcoholic Steatohepatitis Clinical Research Network. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology 2012 Sep;56(3):943-51. Epub 2012 Jul 26.Abstract
Previous studies have shown familial aggregation of insulin resistance and nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to examine whether family history of diabetes mellitus (DM) is associated with nonalcoholic steatohepatitis (NASH) and fibrosis in patients with NAFLD. This was a cross-sectional analysis in participants of the NAFLD Database study and PIVENS trial who had available data on family history of DM. One thousand and sixty-nine patients (63% women), with mean age of 49.6 (± 11.8) years and body mass index (BMI) of 34.2 (± 6.4) kg/m(2) , were included. Thirty percent had DM, and 56% had a family history of DM. Both personal history of DM and family history of DM were significantly associated with NASH, with an odds ratio (OR) of 1.93 (95% confidence interval [CI]: 1.37-2.73; P <0.001) and 1.48 (95% CI: 1.11-1.97; P = 0.01) and any fibrosis with an OR of 3.31 (95% CI: 2.26-4.85; P < 0.001) and 1.66 (95% CI: 1.25-2.20; P < 0.001), respectively. When the models were adjusted for age, sex, BMI, ethnicity, and metabolic traits, the association between diabetes and family history of DM with NASH showed an increased adjusted OR of 1.76 (95% CI: 1.13-2.72; P < 0.001) and 1.34 (95% CI: 0.99-1.81; P = 0.06), respectively, and with any fibrosis with a significant adjusted OR of 2.57 (95% CI: 1.61-4.11; P < 0.0001) and 1.38 (95% CI: 1.02-1.87; P = 0.04), respectively. After excluding patients with personal history of diabetes, family history of DM was significantly associated with the presence of NASH and any fibrosis with an adjusted OR of 1.51 (95% CI: 1.01-2.25; P = 0.04) and 1.49 (95% CI: 1.01-2.20; P = 0.04), respectively.