An official website of the United States government
Publication Information
PubMed ID
Public Release Type
Journal
Publication Year
2012
Affiliation
Mayo Clinic, Rochester, MN, USA.
Authors
Abell TL, Bernard CE, Farrugia G, Gibbons S, Grover M, Kendrick M, Nguyen LA, Ordog T, Parkman HP, Pasricha PJ, Sarr M, Shen KR, Snape W, Swain J
Studies
Citation
Grover M, Bernard CE, Pasricha PJ, Parkman HP, Abell TL, Nguyen LA, Snape W, Shen KR, Sarr M, Swain J, Kendrick M, Gibbons S, Ordog T, Farrugia G. Platelet-derived growth factor receptor α (PDGFRα)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans. Neurogastroenterol Motil 2012 Sep;24(9):844-52. Epub 2012 Jun 1.Abstract
Emerging evidence suggests that "fibroblast-like cells" (FLC) may play a role in the regulation of gastrointestinal (GI) motor function. FLC are ultrastructurally distinct from other interstitial cells, including interstitial cells of Cajal (ICC), and express small-conductance Ca(2+) -activated K(+) channels (SK3). In mice, platelet-derived growth factor receptor α (PDGFRα) antibody has also been shown to label FLC. The aims of this study were to determine the morphology and distribution of PDGFRα-immunoreactive (ir) FLC in human gastric muscle and to determine if FLC are altered in gastroparesis, where ICC are reduced.