PubMed ID:
22650155
Public Release Type:
Journal
Publication Year: 2012
Affiliation: Mayo Clinic, Rochester, MN, USA.
DOI:
https://doi.org/10.1111/j.1365-2982.2012.01944.x
Authors:
Abell TL,
Bernard CE,
Farrugia G,
Gibbons S,
Grover M,
Kendrick M,
Nguyen LA,
Ordog T,
Parkman HP,
Pasricha PJ,
Sarr M,
Shen KR,
Snape W,
Swain J
Studies:
Gastroparesis Clinical Research Consortium
,
Nortriptyline for Idiopathic Gastroparesis
Emerging evidence suggests that "fibroblast-like cells" (FLC) may play a role in the regulation of gastrointestinal (GI) motor function. FLC are ultrastructurally distinct from other interstitial cells, including interstitial cells of Cajal (ICC), and express small-conductance Ca(2+) -activated K(+) channels (SK3). In mice, platelet-derived growth factor receptor α (PDGFRα) antibody has also been shown to label FLC. The aims of this study were to determine the morphology and distribution of PDGFRα-immunoreactive (ir) FLC in human gastric muscle and to determine if FLC are altered in gastroparesis, where ICC are reduced.