NIDDK Central Repository - Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping.

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NIDDK Central Repository

Publication Information

DOI

10.1053/j.gastro.2012.05.036

PubMed ID

22643349

Public Release Type

Journal

Publication Year

2012

Affiliation

Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; Department of Surgery, Vanderbilt University, Nashville, Tennessee.

Authors

Abell TL, Angeli TR, Cheng LK, Du P, Farrugia G, Lahr C, Lammers WJEP, O'Grady G, Pullan AJ, Windsor JA

Studies

NORIG

Citation

O'Grady G, Angeli TR, Du P, Lahr C, Lammers WJEP, Windsor JA, Abell TL, Farrugia G, Pullan AJ, Cheng LK. Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping. Gastroenterology 2012 Sep;143(3):589-598.e3. Epub 2012 May 27.

Abstract

Interstitial cells of Cajal (ICC) generate slow waves. Disrupted ICC networks and gastric dysrhythmias are each associated with gastroparesis. However, there are no data on the initiation and propagation of slow waves in gastroparesis because research tools have lacked spatial resolution. We applied high-resolution electrical mapping to quantify and classify gastroparesis slow-wave abnormalities in spatiotemporal detail.