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Publication Information
Affiliation
Department of Medical Genetics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. jason.cooper@cimr.cam.ac.uk
Authors
Akolkar B, Concannon P, Cooper JD, Eisenbarth GS, Erlich HA, Howson JM, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rewers M, Rich SS, She JX, Smyth D, Stevens H, Todd JA, Type 1 Diabetes Genetics Consortium, Walker NM, Yang JH
Studies
Citation
Cooper JD, Howson JM, Smyth D, Walker NM, Stevens H, Yang JH, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rich SS, Type 1 Diabetes Genetics Consortium. Confirmation of novel type 1 diabetes risk loci in families. Diabetologia 2012 Apr;55(4):996-1000. Epub 2012 Jan 26.Abstract
Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.