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Publication Information
Affiliation
Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands.
Authors
Amin N, Aulchenko YS, Band G, Barroso I, Bellenguez C, Bergen AA, Blackburn H, Blackwell JM, Bramon E, Brown MA, Bumpstead SJ, Carbonaro F, Casas JP, Corvin A, Czudowska MA, DCCT/EDIC Research Group, de Jong PT, Deloukas P, Despriet DD, Donnelly P, Dronov S, Duncanson A, Edkins S, Foster PJ, Freeman C, Giannoulatou E, Gillman M, Gramer E, Gray E, Gwilliam R, Hammond CJ, Hammond N, Hellenthal G, Hewitt AW, Hofman A, Hosseini SM, Hunt SE, Hysi PG, Ikram MK, Jankowski J, Jansonius NM, Janssen SF, Jayakumar A, Klaver CC, Kramer R, Langford C, Lemij HG, Liddle J, Macgregor S, Mackey DA, Mardin CY, Markus HS, Mathew CG, McCann OT, McCarthy MI, McGuffin P, Mitchell P, Montgomery GW, Oostra BA, Palmer CN, Pasutto F, Paterson AD, Pearson R, Pirinen M, Plomin R, Potter SC, Ramdas WD, Rautanen A, Ravindrarajah R, Reis A, Ricketts M, Rivadeneira F, Sawcer SJ, Spencer CC, Strange A, Struchalin M, Su Z, ten Brink JB, Topouzis F, Trembath RC, Uitterlinden AG, van Duijn CM, van Koolwijk LM, Vingerling JR, Viswanathan AC, Vukcevic D, Waller M, Wang JJ, Weisschuh N, Welge-Lüssen U, Wellcome Trust Case Control Consortium 2, Weston P, Whittaker P, Widaa S, Willemse-Assink JJ, Wolfs RC, Wong TY, Wood NW, Young TL, Zenkel M
Studies
Citation
van Koolwijk LM, Ramdas WD, Ikram MK, Jansonius NM, Pasutto F, Hysi PG, Macgregor S, Janssen SF, Hewitt AW, Viswanathan AC, ten Brink JB, Hosseini SM, Amin N, Despriet DD, Willemse-Assink JJ, Kramer R, Rivadeneira F, Struchalin M, Aulchenko YS, Weisschuh N, Zenkel M, Mardin CY, Gramer E, Welge-Lüssen U, Montgomery GW, Carbonaro F, Young TL, DCCT/EDIC Research Group, Bellenguez C, McGuffin P, Foster PJ, Topouzis F, Mitchell P, Wang JJ, Wong TY, Czudowska MA, Hofman A, Uitterlinden AG, Wolfs RC, de Jong PT, Oostra BA, Paterson AD, Wellcome Trust Case Control Consortium 2, Mackey DA, Bergen AA, Reis A, Hammond CJ, Vingerling JR, Lemij HG, Klaver CC, van Duijn CM. Common genetic determinants of intraocular pressure and primary open-angle glaucoma. PLoS Genet 2012;8(5):e1002611. Epub 2012 May 3.Abstract
Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic factors which determine IOP are largely unknown. We performed a genome-wide association study for IOP in 11,972 participants from 4 independent population-based studies in The Netherlands. We replicated our findings in 7,482 participants from 4 additional cohorts from the UK, Australia, Canada, and the Wellcome Trust Case-Control Consortium 2/Blue Mountains Eye Study. IOP was significantly associated with rs11656696, located in GAS7 at 17p13.1 (p=1.4×10(-8)), and with rs7555523, located in TMCO1 at 1q24.1 (p=1.6×10(-8)). In a meta-analysis of 4 case-control studies (total N = 1,432 glaucoma cases), both variants also showed evidence for association with glaucoma (p=2.4×10(-2) for rs11656696 and p=9.1×10(-4) for rs7555523). GAS7 and TMCO1 are highly expressed in the ciliary body and trabecular meshwork as well as in the lamina cribrosa, optic nerve, and retina. Both genes functionally interact with known glaucoma disease genes. These data suggest that we have identified two clinically relevant genes involved in IOP regulation.