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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2012
Affiliation
Nutrition and Neurocognition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. troen@agri.huji.ac.il
Authors
Alfrey EJ, Anandagoda Lde S, Anderson-Haag T, Armbruster B, Berndt M, Blackmore J, Bolin P Jr, Bolognani S, Bostom A, Bresnahan B, Bryant W, Bullas R, Carpenter MA, Clark R, Coffman J, Cole E, Cosio F, Dallal GE, D'Anci KE, Diltz C, Dobson B, Edgar MJ, Edwards C, FACT Study Investigators, Famure S, Farag YM, Ford H, Garris C, Garrison K, Gaynor S, Gifford-Hollingsworth C, Giordan M, Gnadt C, Groth J, Hertello P, House A, Hunsicker L, Jacques PF, Jones P, Kasiske B, Kendrach A, Kew CE 2nd, Kumar A, LaBeck T, Levey AS, Lion M, Lowe T, Lyman PR, Mace N, Mahler K, McDaniel B, McKenney J, McRae E, Medeiros M, Miedwig L, Moorthy D, Norman D, Okano I, Osborne J, Pacheco-Silva A, Pagels J, Parker K, Parks R, Pence D, Pesavento T, Pirsch J, Quintino P, Radke N, Riley J, Rogers G, Rosenberg IH, Sanmugalingham G, Scott TM, Selhub J, Seliger S, Singh A, Smith SR, Sundberg AK, Troen AM, Vella J, Vermillion M, Wallace W, Weiner DE, Weir M, Young C
Studies
Citation
Troen AM, Scott TM, D'Anci KE, Moorthy D, Dobson B, Rogers G, Weiner DE, Levey AS, Dallal GE, Jacques PF, Selhub J, Rosenberg IH, FACT Study Investigators. Cognitive dysfunction and depression in adult kidney transplant recipients: baseline findings from the FAVORIT Ancillary Cognitive Trial (FACT). J Ren Nutr 2012 Mar;22(2):268-76.e1-3. Epub 2011 Dec 6.

Abstract

Hyperhomocysteinemia and B-vitamin deficiency may be treatable risk factors for cognitive impairment and decline. Hyperhomocysteinemia, cognitive impairment, and depression are all common in individuals with kidney disease, including kidney transplant recipients. Accordingly, we assessed the prevalence of cognitive impairment and depressive symptoms in transplant recipients and their association with kidney function, plasma total homocysteine, and B-vitamin concentrations.