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Public Release Type:
Journal
Publication Year: 2011
Authors:
Abrams SH,
Molleston JP,
Lavine JE,
Schwimmer JB,
Sanyal AJ,
Brunt EM,
Kleiner DE,
Unalp A,
Wang J,
Wilson L,
Chalasani NP,
Murray KF,
Rosenthal P,
Bell LN
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
,
Treatment of Nonalcoholic Fatty Liver Disease in Children
Results from the TONIC [“Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in Children”] (JAMA 2011; 305:1659-1668) trial showed that vitamin E but not metformin improves liver histology in children with NAFLD. Adipose tissue insulin resistance is thought to be involved in the pathogenesis of NAFLD and nonalcoholic steatohepatitis (NASH); therefore, we assessed changes in adipose tissue insulin resistance and their relationship to changes in alanine aminotransferase (ALT) and liver histology in children who participated in TONIC.
