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Publication Information
Affiliation
Authors
Abrams SH, Bell LN, Brunt EM, Chalasani NP, Kleiner DE, Lavine JE, Molleston JP, Murray KF, Rosenthal P, Sanyal AJ, Schwimmer JB, Unalp A, Wang J, Wilson L
Studies
Citation
Bell LN, Molleston JP, Lavine JE, Schwimmer JB, Murray KF, Rosenthal P, Abrams SH, Sanyal AJ, Brunt EM, Kleiner DE, Unalp A, Wang J, Wilson L, Chalasani NP. Changes in adipose tissue insulin resistance correlate with changes in ALT and lobular inflammation in children enrolled in the TONIC trial. Hepatology 2011 Oct;54(Supplement S1):711A.Abstract
Results from the TONIC [“Treatment of Nonalcoholic
Fatty Liver Disease (NAFLD) in Children”] (JAMA 2011;
305:1659-1668) trial showed that vitamin E but not metformin
improves liver histology in children with NAFLD. Adipose tissue
insulin resistance is thought to be involved in the pathogenesis
of NAFLD and nonalcoholic steatohepatitis (NASH); therefore,
we assessed changes in adipose tissue insulin resistance and
their relationship to changes in alanine aminotransferase (ALT)
and liver histology in children who participated in TONIC.