PubMed ID:
21812969
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
DOI:
https://doi.org/10.1186/1471-2350-12-104
Authors:
Liu X,
Andrews H,
Browne A,
Cheng R,
Clark LN,
Cote LJ,
Fahn S,
Ford B,
Frucht S,
Kisselev S,
Lee JH,
Louis ED,
Marder K,
Mejia-Sanatana H,
Verbitsky M,
Waters C
Studies:
Inflammatory Bowel Disease Genetics
To date, nine Parkinson disease (PD) genome-wide association studies in North American, European and Asian populations have been published. The majority of studies have confirmed the association of the previously identified genetic risk factors, SNCA and MAPT, and two studies have identified three new PD susceptibility loci/genes (PARK16, BST1 and HLA-DRB5). In a recent meta-analysis of datasets from five of the published PD GWAS an additional 6 novel candidate genes (SYT11, ACMSD, STK39, MCCC1/LAMP3, GAK and CCDC62/HIP1R) were identified. Collectively the associations identified in these GWAS account for only a small proportion of the estimated total heritability of PD suggesting that an 'unknown' component of the genetic architecture of PD remains to be identified.