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Publication Information
Affiliation
University of South Florida, Pediatrics Epidemiology Center, Tampa, FL, USA. kendra.vehik@epi.usf.edu
Authors
Beam CA, Haller MJ, Krischer JP, Mahon JL, Schatz DA, Skyler JS, Sosenko JM, TrialNet Natural History Study Group, Vehik K
Studies
Citation
Vehik K, Beam CA, Mahon JL, Schatz DA, Haller MJ, Sosenko JM, Skyler JS, Krischer JP, TrialNet Natural History Study Group. Development of autoantibodies in the TrialNet Natural History Study. Diabetes Care 2011 Sep;34(9):1897-901. Epub 2011 Jul 12.Abstract
Understanding the relationship between age and islet autoantibody (Ab) seroconversion can establish the optimal screening interval(s) to assess risk for type 1 diabetes, identify subjects who can participate in prevention trials, and determine associated costs. This study assessed the rates of seroconversion to glutamic acid decarboxylase positive (GAD65(+)), insulin positive (mIAA(+)), and insulinoma-associated protein 2 positive (ICA512(+)) in a large cohort of relatives of type 1 diabetes probands undergoing Ab rescreening in the TrialNet Natural History Study.