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Publication Information
Affiliation
Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA. pramos@wfubmc.edu
Authors
Alarcón GS, Alarcón-Riquelme ME, Brown EE, Comeau ME, Criswell LA, Edberg JC, Gaffney PM, Graham DC, Graham RR, Guy RT, Harley JB, Jacob CO, Kaufman KM, Kelly JA, Kimberly RP, Langefeld CD, Lessard CJ, Li H, McGwin G, Moser KL, Petri MA, Ramos PS, Ramsey-Goldman R, Reveille JD, Tsao BP, Vilá LM, Vyse TJ, Williams AH, Zidovetzki R, Ziegler JT
Studies
Citation
Ramos PS, Williams AH, Ziegler JT, Comeau ME, Guy RT, Lessard CJ, Li H, Edberg JC, Zidovetzki R, Criswell LA, Gaffney PM, Graham DC, Graham RR, Kelly JA, Kaufman KM, Brown EE, Alarcón GS, Petri MA, Reveille JD, McGwin G, Vilá LM, Ramsey-Goldman R, Jacob CO, Vyse TJ, Tsao BP, Harley JB, Kimberly RP, Alarcón-Riquelme ME, Langefeld CD, Moser KL. Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis Rheum 2011 Jul;63(7):2049-57.Abstract
The overexpression of interferon (IFN)-inducible genes is a prominent feature of systemic lupus erythematosus (SLE); it serves as a marker for active and more severe disease, and is also observed in other autoimmune and inflammatory conditions. This study was undertaken to investigate the genetic variations responsible for sustained activation of IFN-responsive genes in SLE.