PubMed ID:
21437871
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA. pramos@wfubmc.edu
DOI:
https://doi.org/10.1002/art.30356
Authors:
Alarcón GS,
Alarcón-Riquelme ME,
Brown EE,
Comeau ME,
Criswell LA,
Edberg JC,
Gaffney PM,
Graham DC,
Graham RR,
Guy RT,
Harley JB,
Jacob CO,
Kaufman KM,
Kelly JA,
Kimberly RP,
Langefeld CD,
Lessard CJ,
Li H,
McGwin G,
Moser KL,
Petri MA,
Ramos PS,
Ramsey-Goldman R,
Reveille JD,
Tsao BP,
Vilá LM,
Vyse TJ,
Williams AH,
Zidovetzki R,
Ziegler JT
Studies:
Inflammatory Bowel Disease Genetics
The overexpression of interferon (IFN)-inducible genes is a prominent feature of systemic lupus erythematosus (SLE); it serves as a marker for active and more severe disease, and is also observed in other autoimmune and inflammatory conditions. This study was undertaken to investigate the genetic variations responsible for sustained activation of IFN-responsive genes in SLE.