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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2011
Affiliation
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University, New York, New York, USA. jl3553@columbia.edu
Authors
Abdelmalek MF, Abrams SH, Ackermann S, Barlow S, Bass NM, Behling C, Belt P, Boyett S, Brunt EM, Bryan D, Buse J, Chalasani N, Clark JM, Colvin R, Contos MJ, Cummings OW, Dasarathy S, Derdoy J, Diehl AM, Donithan M, Doo EC, Durelle J, Fairly LA, Ferrell LD, Filipowski D, Fuchs M, Green M, Guy C, Hawkins C, Hoffmann JA, Hoofnagle JH, Huang TT, Isaacson M, Jin WK, Jonas M, Jones A, Kleiner DE, Klipsch A, Kowdley KV, Lavine JE, Lee W, Liu YC, Loomba R, Luketic VA, McCullough AJ, Merriman R, Miriel LA, Mohan P, Molleston JP, Morgan T, Murray KF, Nair K, Nelson J, Neuschwander-Tetri BA, Nonalcoholic Steatohepatitis Clinical Research Network, Pabst M, Pan YP, Pfeifer K, Piercy D, Ragozzino L, Rand E, Reboussin DM, Robuck PR, Rosenthal P, Rose S, Sandhu B, Sanyal AJ, Sargeant C, Sargent R, Scheimann AO, Schwimmer JB, Shaw C, Siegner J, Smith M, Stager M, Stein T, Sternberg A, Stewart S, Subbarao G, Thompson J, Tonascia J, Torbenson M, Ünalp A, Van Natta ML, Vaughn I, Vuppalanchi R, White M, Whitwell J, Wilson LA, Yates KP, Yeh M, Young M
Studies
Citation
Lavine JE, Schwimmer JB, Van Natta ML, Molleston JP, Murray KF, Rosenthal P, Abrams SH, Scheimann AO, Sanyal AJ, Chalasani N, Tonascia J, Ünalp A, Clark JM, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR, Nonalcoholic Steatohepatitis Clinical Research Network. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 2011 Apr 27;305(16):1659-68.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in US children and adolescents and can present with advanced fibrosis or nonalcoholic steatohepatitis (NASH). No treatment has been established.