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Publication Information
Affiliation
1 Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago; 2 Department of
Pediatrics, University of Pennsylvania, Perelman School of Medicine, Children’s Hospital of Philadelphia
Authors
Alonso EM, Behrens EM, Chapin CA, Diamond T, Harris RM, Loomes KM, Vaccaro O
Studies
Abstract
Between October 2021 and May 2022 there was an increase
in reported cases of acute severe hepatitis of unknown cause
in children
Some progressed to pediatric acute liver failure (PALF) and
required liver transplantation
Human adenovirus (AdV) viremia, specifically type 41, was
identified in many of these cases
Historically AdV has been a rare cause of acute hepatitis, with
case reports in immunocompromised children