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Publication Information
Affiliation
Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Authors
Aasarød K, Akylbekova E, Arking DE, Arnlöv J, Aspelund T, Atkinson EJ, Aulchenko YS, Badola S, Bakker SJ, Baumert J, Beckmann JS, Bergmann S, Biffar R, Blankenberg S, Boban M, Bochud M, Boerwinkle E, Böger CA, Borecki I, Bull SB, Campbell H, Campbell S, Cavalieri M, Chasman DI, Chen MH, CKDGen Consortium, Coassin S, Coresh J, Cupples LA, Curhan G, de Andrade M, de Boer I, de Boer IH, Dehghan A, Devuyst O, Dreisbach AW, Egan J, Eiriksdottir G, Ellinghaus D, Endlich K, Feitosa M, Felix JF, Ferrucci L, Florez JC, Fox CS, Franceschini N, Fuchsberger C, Gao X, Giallauria F, Glazer NL, Gudnason V, Gyllensten U, Hallan S, Haritunians T, Harris TB, Hastie ND, Hayward C, Heid IM, Hernandez D, Hofman A, Hwang SJ, Igl W, Illig T, Imboden M, Ingelsson E, Isaacs A, Johansson Å, Johnson AD, Kao WH, Kardia SL, Kedenko L, Kestenbaum B, Ketkar S, Klopp N, Koenig W, Kolcic I, Kollerits B, Köttgen A, Krämer BK, Kramer H, Kroemer HK, Kronenberg F, Kutalik Z, Launer LJ, Leak TS, Li M, Liu CT, Liu Y, Lohman K, Loos RJ, Luan J, Lumley T, Lu X, Mägi R, Meigs JB, Meisinger C, Metter J, Minelli C, Mitchell BD, Mooser V, Mychaleckyj JC, Nauck M, Navis G, O'Connell JR, Olden M, Oostra BA, O'Seaghdha CM, Paré G, Parker AN, Parsa A, Paterson NJ, Pattaro C, Paulweber B, Peralta CA, Polasek O, Pramstaller PP, Prokopenko I, Province M, Psaty BM, Rampersaud E, Reilly M, Rettig R, Ridker PM, Rivadeneira F, Rotter JI, Rudan I, Schmidt H, Schmidt R, Schreiber S, Shlipak MG, Shuldiner AR, Singleton A, Siscovick D, Siscovick DS, Skorpen F, Smith AV, Stracke S, Struchalin M, Stumvoll M, Syvänen AC, Tanaka T, Teumer A, Tin A, Tönjes A, Townsend RR, Turner ST, Uitterlinden AG, van der Harst P, van Duijn CM, Vitart V, Völker U, Vollenweider P, Völzke H, Waeber G, Wareham NJ, Waterworth D, Wichmann HE, Wild SH, Wilson JF, Witteman JC, Wright AF, Yang Q, Zaboli G, Zemunik T, Zgaga L, Zhao JH, Zillikens MC
Studies
Citation
Böger CA, Chen MH, Tin A, Olden M, Köttgen A, de Boer IH, Fuchsberger C, O'Seaghdha CM, Pattaro C, Teumer A, Liu CT, Glazer NL, Li M, O'Connell JR, Tanaka T, Peralta CA, Kutalik Z, Luan J, Zhao JH, Hwang SJ, Akylbekova E, Kramer H, van der Harst P, Smith AV, Lohman K, de Andrade M, Hayward C, Kollerits B, Tönjes A, Aspelund T, Ingelsson E, Eiriksdottir G, Launer LJ, Harris TB, Shuldiner AR, Mitchell BD, Arking DE, Franceschini N, Boerwinkle E, Egan J, Hernandez D, Reilly M, Townsend RR, Lumley T, Siscovick DS, Psaty BM, Kestenbaum B, Haritunians T, Bergmann S, Vollenweider P, Waeber G, Mooser V, Waterworth D, Johnson AD, Florez JC, Meigs JB, Lu X, Turner ST, Atkinson EJ, Leak TS, Aasarød K, Skorpen F, Syvänen AC, Illig T, Baumert J, Koenig W, Krämer BK, Devuyst O, Mychaleckyj JC, Minelli C, Bakker SJ, Kedenko L, Paulweber B, Coassin S, Endlich K, Kroemer HK, Biffar R, Stracke S, Völzke H, Stumvoll M, Mägi R, Campbell H, Vitart V, Hastie ND, Gudnason V, Kardia SL, Liu Y, Polasek O, Curhan G, Kronenberg F, Prokopenko I, Rudan I, Arnlöv J, Hallan S, Navis G, CKDGen Consortium, Parsa A, Ferrucci L, Coresh J, Shlipak MG, Bull SB, Paterson NJ, Wichmann HE, Wareham NJ, Loos RJ, Rotter JI, Pramstaller PP, Cupples LA, Beckmann JS, Yang Q, Heid IM, Rettig R, Dreisbach AW, Bochud M, Fox CS, Kao WH. CUBN is a gene locus for albuminuria. J Am Soc Nephrol 2011 Mar;22(3):555-70.Abstract
Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 × 10(-11)) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.