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Interaction of onset and duration of diabetes on the percent of GAD and IA-2 antibody-positive subjects in the type 1 diabetes genetics consortium database.

HomePublicationsInteraction of onset and duration of diabetes on the percent of GAD and IA-2 antibody-positive subjects in the type 1 diabetes genetics consortium database.

Publication Information

DOI

10.2337/dc10-1903

PubMed ID

21330643

Public Release Type

Journal

Publication Year

2011

Affiliation

Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington, USA. dtridgell@benaroyaresearch.org

Authors

Greenbaum CJ, Spiekerman C, Tridgell DM, Wang RS

Studies

T1DGC

Citation

Tridgell DM, Spiekerman C, Wang RS, Greenbaum CJ. Interaction of onset and duration of diabetes on the percent of GAD and IA-2 antibody-positive subjects in the type 1 diabetes genetics consortium database. Diabetes Care 2011 Apr;34(4):988-93. Epub 2011 Feb 17.

Abstract

GAD antibodies (GADA) are more common in type 1 diabetic subjects diagnosed at an older age, whereas insulinoma-antigen 2 antibodies (IA-2A) are more common in subjects with younger onset. The prevalence of both antibodies decreases with longer duration of type 1 diabetes. We evaluated the interaction between age of diagnosis (onset) and duration of diabetes on the percentage of GADA- and IA-2A-positive subjects.