PubMed ID:
21330643
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington, USA. dtridgell@benaroyaresearch.org
DOI:
https://doi.org/10.2337/dc10-1903
Authors:
Greenbaum CJ,
Spiekerman C,
Tridgell DM,
Wang RS
Studies:
Type 1 Diabetes Genetics Consortium
GAD antibodies (GADA) are more common in type 1 diabetic subjects diagnosed at an older age, whereas insulinoma-antigen 2 antibodies (IA-2A) are more common in subjects with younger onset. The prevalence of both antibodies decreases with longer duration of type 1 diabetes. We evaluated the interaction between age of diagnosis (onset) and duration of diabetes on the percentage of GADA- and IA-2A-positive subjects.