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Publication Information
Public Release Type
Journal
Publication Year
2011
Authors
Belt PH, Brunt EM, Kleiner DE, Neuschwander-Tetri BA, Wilson LA
Citation
Brunt EM , Kleiner DE , Wilson LA , Belt PH , Neuschwander-Tetri BA. The Nonalcoholic Fatty Liver Disease Activity Score (NAS) and the Histopathologic Diagnosis in Nonalcoholic Fatty Liver Disease: Distinct Clinicopathologic Meanings. Mod Pathol 2011 Feb;24(Supplement 1s):357A-358A.Abstract
The diagnosis (dx) of nonalcoholic steatohepatitis (NASH) is characterized by clinical features and the presence and pattern of specific histological lesions in liver biopsy. Some studies have used threshold values of the nonalcoholic fatty liver disease activity score (NAS), derived from unweighted sum of scores for steatosis (0-3), lobular inflammation (0-2) and ballooning (0-2), specifically NAS ≥ 5, as a surrogate for the histologic dx of NASH.