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Publication Information

DOI
PubMed ID
Public Release Type
Journal
Publication Year
2011
Affiliation
Authors
Abelmalek MF, Belt P, Brunt EM, Burchette JL, Cardona D, Diehl AM, Ferrell LD, Guy CD, McCall SJ, Suzuki A, Unlap A, Wilson L
Studies
Citation
Guy CD , Suzuki A , Burchette JL , Brunt EM , Abelmalek MF , Cardona D , McCall SJ , Unlap A , Belt P , Wilson L , Ferrell LD , Diehl AM. A Novel Immunohiostochemical Staining Pattern for Keratin 8/18 Plus Ubiquitin in Nonalcoholic Fatty Liver Disease Is Associated with Increased Disease Severity and Advanced Fibrosis. Mod Pathol 2011 Feb;24(Supplement 1s):361A.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a global health dilemma. The gold standard for diagnosis is liver biopsy. Ballooned hepatocytes (BH) are histologic manifestations of hepatocellular injury and are characteristic features of steatohepatitis (SH), the more severe and potentially more progressive form of NAFLD. Definitive histologic identification of BH on routine stains, however, can be difficult. Immunohistochemical (IHC) staining for loss of the normal hepatocytic keratin 8/18 (K8/18) can serve as an objective marker of BH. We sought to explore the utility of a K8/18 plus ubiquitin (Ub) double IHC stain for the histologic evaluation of adult NAFLD.