PubMed ID:
21454968
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Genetic Analysis and Data Coordinating Center, Cleveland, Ohio, USA.
DOI:
https://doi.org/10.1159/000326763
Authors:
Kimmel PL,
Hanson RL,
Knowler WC,
Nelson RG,
Abboud H,
Adler SG,
Arar NH,
Bowden DW,
Divers J,
Duggirala R,
Elston RC,
Family Investigation of Nephropathy and Diabetes Research Group,
Freedman BI,
Goddard KA,
Guo X,
Horvath A,
Igo RP Jr,
Ipp E,
Iyengar SK,
Kao WH,
Langefeld CD,
Meoni LA,
Molineros J,
Nicholas SB,
Pahl MV,
Parekh RS,
Rasooly RS,
Schelling JR,
Sedor JR,
Shah VO,
Smith MW,
Winkler CA,
Zager PG
Studies:
Family Investigation of Nephropathy and Diabetes
Diabetic nephropathy (DN) is a leading cause of mortality and morbidity in patients with type 1 and type 2 diabetes. The multicenter FIND consortium aims to identify genes for DN and its associated quantitative traits, e.g. the urine albumin:creatinine ratio (ACR). Herein, the results of whole-genome linkage analysis and a sparse association scan for ACR and a dichotomous DN phenotype are reported in diabetic individuals.