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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2011
Affiliation
Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Lübeck, Deutschland.
Authors
König IR, Loley C, Ziegler A
Studies
Citation
Loley C, Ziegler A, König IR. Association tests for X-chromosomal markers--a comparison of different test statistics. Hum Hered 2011;71(1):23-36. Epub 2011 Feb 16.

Abstract

Genome-wide association studies have successfully elucidated the genetic background of complex diseases, but X chromosomal data have usually not been analyzed. A reason for this is that there is no consensus approach for the analysis taking into account the specific features of X chromosomal data. This contribution evaluates test statistics proposed for X chromosomal markers regarding type I error frequencies and power.