Loley C, Ziegler A, König IR. Association tests for X-chromosomal markers--a comparison of different test statistics. Hum Hered 2011;71(1):23-36. Epub 2011 Feb 16.
Abstract
Genome-wide association studies have successfully elucidated the genetic background of complex diseases, but X chromosomal data have usually not been analyzed. A reason for this is that there is no consensus approach for the analysis taking into account the specific features of X chromosomal data. This contribution evaluates test statistics proposed for X chromosomal markers regarding type I error frequencies and power.