PubMed ID:
21030684
Public Release Type:
Journal
Publication Year: 2011
Affiliation: The Diabetes Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA. dnathan@partners.org
DOI:
https://doi.org/10.1373/clinchem.2010.150250
Authors:
Lachin JM,
Nathan DM,
Rynders GP,
Steffes MW,
Sun W
Studies:
Diabetes Control and Complications Trial
Determining the stability of stored samples for assays that were not available at the time of original collection is problematic. To assess sample stability for a relatively new assay of glycated albumin (GA), we first measured GA in fresh samples and in samples stored for 19-23 years. We then compared the regression of the contemporaneous glycohemoglobin (Hb A(1c)) values against the GA results from fresh vs stored samples, reasoning that similar slopes and intercepts would provide strong, albeit indirect, support for the stability of the stored samples for GA measurements.