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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2011
Affiliation
The Diabetes Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA. dnathan@partners.org
Authors
Lachin JM, Nathan DM, Rynders GP, Steffes MW, Sun W
Studies
Citation
Nathan DM, Steffes MW, Sun W, Rynders GP, Lachin JM. Determining stability of stored samples retrospectively: the validation of glycated albumin. Clin Chem 2011 Feb;57(2):286-90. Epub 2010 Oct 28.

Abstract

Determining the stability of stored samples for assays that were not available at the time of original collection is problematic. To assess sample stability for a relatively new assay of glycated albumin (GA), we first measured GA in fresh samples and in samples stored for 19-23 years. We then compared the regression of the contemporaneous glycohemoglobin (Hb A(1c)) values against the GA results from fresh vs stored samples, reasoning that similar slopes and intercepts would provide strong, albeit indirect, support for the stability of the stored samples for GA measurements.