PubMed ID:
20803190
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Winthrop-University Hospital, Suite 300, 222 Station Plaza North, Mineola, NY 11501, USA. amjacobson@winthrop.org
DOI:
https://doi.org/10.1007/s00125-010-1883-9
Authors:
Cleary PA,
Dahms W,
Diabetes Control and Complications Trial/EDIC Research Group,
Jacobson AM,
Musen G,
Ryan CM,
Waberski BH,
Weinger K
Studies:
Diabetes Control and Complications Trial
In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, smoking, hypercholesterolaemia, obesity), sub-clinical macrovascular disease (carotid intima-media thickening, coronary calcification) and microvascular complications (retinopathy, nephropathy) were associated with decrements in cognitive function over an extended time period.