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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2011
Affiliation
Winthrop-University Hospital, Suite 300, 222 Station Plaza North, Mineola, NY 11501, USA. amjacobson@winthrop.org
Authors
Cleary PA, Dahms W, Diabetes Control and Complications Trial/EDIC Research Group, Jacobson AM, Musen G, Ryan CM, Waberski BH, Weinger K
Studies
Citation
Jacobson AM, Ryan CM, Cleary PA, Waberski BH, Weinger K, Musen G, Dahms W, Diabetes Control and Complications Trial/EDIC Research Group. Biomedical risk factors for decreased cognitive functioning in type 1 diabetes: an 18 year follow-up of the Diabetes Control and Complications Trial (DCCT) cohort. Diabetologia 2011 Feb;54(2):245-55. Epub 2010 Aug 29.

Abstract

In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, smoking, hypercholesterolaemia, obesity), sub-clinical macrovascular disease (carotid intima-media thickening, coronary calcification) and microvascular complications (retinopathy, nephropathy) were associated with decrements in cognitive function over an extended time period.