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Publication Information
Affiliation
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. rpbusui@umich.edu
Authors
Albers JW, Cleary PA, DCCT/EDIC Research Group, Feldman EL, Herman WH, Lachin JM, Low PA, Martin CL, Pop-Busui R, Waberski BH
Studies
Citation
Pop-Busui R, Herman WH, Feldman EL, Low PA, Martin CL, Cleary PA, Waberski BH, Lachin JM, Albers JW, DCCT/EDIC Research Group. DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history. Curr Diab Rep 2010 Aug;10(4):276-82.Abstract
The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therapy in disease progression. The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review.