PubMed ID:
20538000
Public Release Type:
Journal
Publication Year: 2010
Affiliation: Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany. pavel.strnad@uniklinikulm.de
DOI:
https://doi.org/10.1053/j.gastro.2010.06.007
Authors:
Lee WM,
Acute Liver Failure Study Group,
Davern TJ,
Hanada S,
Lazzeroni LC,
Omary MB,
So P,
Strnad P,
Zhong BH,
Zhou Q
Studies:
Acute Liver Failure Study Group: Adult Acute Liver Failure Study
Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in animal models, has not been studied in humans.