NIDDK Central Repository - Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.

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NIDDK Central Repository

Publication Information

DOI

10.1053/j.gastro.2010.06.007

PubMed ID

20538000

Public Release Type

Journal

Publication Year

2010

Affiliation

Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany. pavel.strnad@uniklinikulm.de

Authors

Acute Liver Failure Study Group, Davern TJ, Hanada S, Lazzeroni LC, Lee WM, Omary MB, So P, Strnad P, Zhong BH, Zhou Q

Studies

AALF

Citation

Strnad P, Zhou Q, Hanada S, Lazzeroni LC, Zhong BH, So P, Davern TJ, Lee WM, Acute Liver Failure Study Group, Omary MB. Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations. Gastroenterology 2010 Sep;139(3):828-35, 835.e1-3. Epub 2010 Jun 9.

Abstract

Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in animal models, has not been studied in humans.