PubMed ID:
20140258
Public Release Type:
Journal
Publication Year: 2010
Affiliation: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America.
DOI:
https://doi.org/10.1371/journal.pone.0009032
Authors:
Aurora R,
Cannon NA,
Di Bisceglie AM,
Donlin MJ,
Li J,
Tavis JE,
Virahep-C Study Group,
Wahed AS
Studies:
Viral Resistance to Antiviral Therapy of Chronic Hepatitis C
Hepatitis C virus (HCV) has six major genotypes, and patients infected with genotype 1 respond less well to interferon-based therapy than other genotypes. African American patients respond to interferon alpha-based therapy at about half the rate of Caucasian Americans. The effect of HCV's genetic variation on treatment outcome in both racial groups is poorly understood.