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Publication Information
Affiliation
Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Authors
Akolkar B, Bonella P, Boyle S, Carlson JA, Erlich HA, Fear AL, Helmberg W, Hilner JE, Kim S, Lane JA, Lavant E, Louey A, Moonsamy PV, Mychaleckyj JC, Noble JA, Perdue LH, Pierce JJ, Post J, Rappner R, Reboussin DM, Sali P, Steffes MW, T1DGC, Tait BD, Varney MD, Williams DT
Studies
Citation
Mychaleckyj JC, Noble JA, Moonsamy PV, Carlson JA, Varney MD, Post J, Helmberg W, Pierce JJ, Bonella P, Fear AL, Lavant E, Louey A, Boyle S, Lane JA, Sali P, Kim S, Rappner R, Williams DT, Perdue LH, Reboussin DM, Tait BD, Akolkar B, Hilner JE, Steffes MW, Erlich HA, T1DGC. HLA genotyping in the international Type 1 Diabetes Genetics Consortium. Clin Trials 2010;7(1 Suppl):S75-87. Epub 2010 Jul 1.Abstract
Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loci in all affected sibling pair and trio families, and cases and controls, recruited from four networks worldwide, for analysis with clinical phenotypes and immunological markers.