PubMed ID:
20595243
Public Release Type:
Journal
Publication Year: 2010
Affiliation: Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
DOI:
https://doi.org/10.1177/1740774510373494
Authors:
Kim S,
Akolkar B,
Bonella P,
Boyle S,
Carlson JA,
Erlich HA,
Fear AL,
Helmberg W,
Hilner JE,
Lane JA,
Lavant E,
Louey A,
Moonsamy PV,
Mychaleckyj JC,
Noble JA,
Perdue LH,
Pierce JJ,
Post J,
Rappner R,
Reboussin DM,
Sali P,
Steffes MW,
T1DGC,
Tait BD,
Varney MD,
Williams DT
Studies:
Type 1 Diabetes Genetics Consortium
Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loci in all affected sibling pair and trio families, and cases and controls, recruited from four networks worldwide, for analysis with clinical phenotypes and immunological markers.