NIDDK Central Repository - A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.

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NIDDK Central Repository

Publication Information

DOI

10.2337/db09-0653

PubMed ID

19875614

Public Release Type

Journal

Publication Year

2010

Affiliation

Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada. andrew.paterson@utoronto.ca

Authors

Below JE, Bharaj B, Boright AP, Bull SB, Canty AJ, Cleary PA, Cox NJ, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group, Hosseini SM, Lachin JM, MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium), Nicolae D, Paterson AD, Shen E, Sun L, Sylvestre MP, Waggott D, Wong I

Studies

DCCT

Citation

Paterson AD, Waggott D, Boright AP, Hosseini SM, Shen E, Sylvestre MP, Wong I, Bharaj B, Cleary PA, Lachin JM, MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium), Below JE, Nicolae D, Cox NJ, Canty AJ, Sun L, Bull SB, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. Diabetes 2010 Feb;59(2):539-49. Epub 2009 Oct 29.

Abstract

Glycemia is a major risk factor for the development of long-term complications in type 1 diabetes; however, no specific genetic loci have been identified for glycemic control in individuals with type 1 diabetes. To identify such loci in type 1 diabetes, we analyzed longitudinal repeated measures of A1C from the Diabetes Control and Complications Trial.