NIDDK Central Repository - Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus.

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NIDDK Central Repository

Publication Information

DOI

10.1007/s00125-009-1281-3

PubMed ID

19247629

Public Release Type

Journal

Publication Year

2009

Affiliation

Nephrology Research Group, Queen's University of Belfast, c/o Regional Genetics Centre, Belfast City Hospital, Belfast, Northern Ireland, UK. a.j.mcknight@qub.ac.uk

Authors

Forsblom C, Groop PH, Maxwell AP, McKnight AJ, Parkkonen M, Patterson CC, Pettigrew KA, Sadlier D, Savage DA, Warren 3/UK GoKinD Study Group, Woodman AM

Studies

GoKinD

Citation

McKnight AJ, Woodman AM, Parkkonen M, Patterson CC, Savage DA, Forsblom C, Pettigrew KA, Sadlier D, Groop PH, Maxwell AP, Warren 3/UK GoKinD Study Group. Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus. Diabetologia 2009 May;52(5):844-9. Epub 2009 Feb 27.

Abstract

SMAD proteins are involved in multiple signalling pathways and are key modulators of gene expression. We hypothesised that genetic variation in selected SMAD genes contributes to susceptibility to diabetic nephropathy.