PubMed ID:
19143820
Public Release Type:
Journal
Publication Year: 2009
Affiliation: Department of Medicine, Division of Endocrinology, University Hospital Frankfurt, Frankfurt am Main, Germany. badenhoop@em.uni-frankfurt.de
DOI:
https://doi.org/10.1111/j.1463-1326.2008.01008.x
Authors:
Badenhoop K,
Böhm BO,
Diabetes Genetics Consortium,
Kahles H,
Kordonouri O,
Lopez ER,
Rosinger S,
Seidl C,
Walter M,
Ziegler A
Studies:
Type 1 Diabetes Genetics Consortium
The region on chromosome 6p21 (IDDM1) confers the largest part of genetic susceptibility to type 1 diabetes (T1D) with particular human leucocyte antigen (HLA) alleles predisposing and others protecting from it. As T1D is primarily a "sporadic" disease, the pathophysiology must involve gene-environment interactions. We searched for indirect evidence for such major histocompatibility complex (MHC)-environment interactions by asking two questions: (i) can the degree of an HLA association vary over time periods? and (ii) if a prenatal event like an intrauterine infection - that might cluster in seasons - leads to differences of HLA associations in patients with particular birth months?