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PubMed ID:
19143818
Public Release Type:
Journal
Publication Year: 2009
Affiliation: Division of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.
DOI:
https://doi.org/10.1111/j.1463-1326.2008.01006.x
Authors:
Bronson PG,
Ramsay PP,
Thomson G,
Barcellos LF,
Diabetes Genetics Consortium
Studies:
Type 1 Diabetes Genetics Consortium
Type 1 diabetes (T1D) is a complex trait for which variation in the classical human leucocyte antigen (HLA) loci within the Major Histocompatibility Complex (MHC) significantly influences disease risk. To date, HLA class II DR-DQ genes confer the strongest known genetic effect in T1D. HLA loci may also influence T1D through additional inherited or non-inherited effects. Evidence for the role of increased maternal-offspring HLA compatibility, and both parent-of-origin (POO) and non-inherited maternal HLA (NIMA) effects in autoimmune disease has been previously established. The current study tested hypotheses that classical HLA loci influence T1D through these mechanisms, in addition to genetic transmission of particular risk alleles.
