NIDDK Central Repository - Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.

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NIDDK Central Repository

Publication Information

DOI

10.1111/j.1463-1326.2008.01001.x

PubMed ID

19143813

Public Release Type

Journal

Publication Year

2009

Affiliation

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. joanna.howson@cimr.cam.ac.uk

Authors

Clayton D, Howson JM, Todd JA, Type 1 Diabetes Genetics Consortium, Walker NM

Studies

T1DGC

Citation

Howson JM, Walker NM, Clayton D, Todd JA, Type 1 Diabetes Genetics Consortium. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab 2009 Feb;11 Suppl 1:31-45.

Abstract

Until recently, human leucocyte antigen (HLA) class II-independent associations with type 1 diabetes (T1D) in the Major Histocompatibility Complex (MHC) region were not adequately characterized owing to insufficient map coverage, inadequate statistical approaches and strong linkage disequilibrium spanning the entire MHC. Here we test for HLA class II-independent associations in the MHC using fine mapping data generated by the Type 1 Diabetes Genetics Consortium (T1DGC).