PubMed ID:
19143822
Public Release Type:
Journal
Publication Year: 2009
Affiliation: Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia. i.james@murdoch.edu.au
DOI:
https://doi.org/10.1111/j.1463-1326.2008.01010.x
Authors:
Diabetes Genetics Consortium,
Gaudieri S,
James I,
McKinnon E,
Morahan G
Studies:
Type 1 Diabetes Genetics Consortium
The absence or 'missingness' of single nucleotide polymorphism (SNP) assay values because of genotype or related factors of interest may bias association and other studies. Missingness was determined for the Type 1 Diabetes Genetics Consortium (T1DGC) Major Histocompatibility Complex (MHC) data and was found to vary across the region, ranging up to 11.1% of the non-null proband SNPs, with a median of 0.3%. We consider factors related to missingness in the T1DGC data and briefly assess its possible influence on association studies.