NIDDK Central Repository - Missingness in the T1DGC MHC fine-mapping SNP data: association with HLA genotype and potential influence on genetic association studies.

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NIDDK Central Repository

Publication Information

DOI

10.1111/j.1463-1326.2008.01010.x

PubMed ID

19143822

Public Release Type

Journal

Publication Year

2009

Affiliation

Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia. i.james@murdoch.edu.au

Authors

Diabetes Genetics Consortium, Gaudieri S, James I, McKinnon E, Morahan G

Studies

T1DGC

Citation

James I, McKinnon E, Gaudieri S, Morahan G, Diabetes Genetics Consortium. Missingness in the T1DGC MHC fine-mapping SNP data: association with HLA genotype and potential influence on genetic association studies. Diabetes Obes Metab 2009 Feb;11 Suppl 1:101-7.

Abstract

The absence or 'missingness' of single nucleotide polymorphism (SNP) assay values because of genotype or related factors of interest may bias association and other studies. Missingness was determined for the Type 1 Diabetes Genetics Consortium (T1DGC) Major Histocompatibility Complex (MHC) data and was found to vary across the region, ranging up to 11.1% of the non-null proband SNPs, with a median of 0.3%. We consider factors related to missingness in the T1DGC data and briefly assess its possible influence on association studies.