NIDDK Central Repository - Mating in parents of type 1 diabetes families as a function of the HLA DR-DQ haplotype.

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NIDDK Central Repository

Publication Information

DOI

10.1111/j.1463-1326.2008.01007.x

PubMed ID

19143819

Public Release Type

Journal

Publication Year

2009

Affiliation

Division of Endocrinology and Department of Immunohaematology, University Hospital Frankfurt, Frankfurt, Germany.

Authors

Badenhoop K, Boehm BO, Diabetes Genetics Consortium, Kahles H, Kordonouri O, Ramos Lopez E, Rosinger S, Seidl C, Walter M, Ziegler A

Studies

T1DGC

Citation

Kahles H, Kordonouri O, Ramos Lopez E, Walter M, Rosinger S, Boehm BO, Badenhoop K, Seidl C, Ziegler A, Diabetes Genetics Consortium. Mating in parents of type 1 diabetes families as a function of the HLA DR-DQ haplotype. Diabetes Obes Metab 2009 Feb;11 Suppl 1:84-7.

Abstract

The Major Histocompatibility Complex (MHC) region on chromosome 6p21 (IDDM1) contributes about half of the familial clustering of type 1 diabetes (T1D). Several studies have revealed that highly polymorphic genes within the MHC may associate with the mating choice. Our study should determine whether a specific mating effect is detectable in T1D families as a function of human leucocyte antigen (HLA) DR-DQ, which could contribute to disease susceptibility.