PubMed ID:
19143819
Public Release Type:
Journal
Publication Year: 2009
Affiliation: Division of Endocrinology and Department of Immunohaematology, University Hospital Frankfurt, Frankfurt, Germany.
DOI:
https://doi.org/10.1111/j.1463-1326.2008.01007.x
Authors:
Badenhoop K,
Boehm BO,
Diabetes Genetics Consortium,
Kahles H,
Kordonouri O,
Ramos Lopez E,
Rosinger S,
Seidl C,
Walter M,
Ziegler A
Studies:
Type 1 Diabetes Genetics Consortium
The Major Histocompatibility Complex (MHC) region on chromosome 6p21 (IDDM1) contributes about half of the familial clustering of type 1 diabetes (T1D). Several studies have revealed that highly polymorphic genes within the MHC may associate with the mating choice. Our study should determine whether a specific mating effect is detectable in T1D families as a function of human leucocyte antigen (HLA) DR-DQ, which could contribute to disease susceptibility.