PubMed ID:
19143821
Public Release Type:
Journal
Publication Year: 2009
Affiliation: Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia. e.mckinnon@murdoch.edu.au
DOI:
https://doi.org/10.1111/j.1463-1326.2008.01009.x
Authors:
Diabetes Genetics Consortium,
James I,
McKinnon E,
Morahan G,
Nolan D
Studies:
Type 1 Diabetes Genetics Consortium
The Major Histocompatibility Complex (MHC) is a highly polymorphic region on chromosome 6 encompassing the human leucocyte antigen (HLA)-DQ/DR loci most predictive of susceptibility to type 1 diabetes (T1D). To assess the contribution of other MHC genes, in this exploratory analysis of Type 1 Diabetes Genetics Consortium (T1DGC) family data we characterize association between susceptibility and MHC single nucleotide polymorphism (SNP) genotype, with an emphasis on effects of genetic variation additional to carriage of predisposing or protective MHC haplotypes.