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Publication Information
PubMed ID
Public Release Type
Journal
Publication Year
2009
Affiliation
Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia. e.mckinnon@murdoch.edu.au
Authors
Diabetes Genetics Consortium, James I, McKinnon E, Morahan G, Nolan D
Studies
Citation
McKinnon E, Morahan G, Nolan D, James I, Diabetes Genetics Consortium. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. Diabetes Obes Metab 2009 Feb;11 Suppl 1:92-100.Abstract
The Major Histocompatibility Complex (MHC) is a highly polymorphic region on chromosome 6 encompassing the human leucocyte antigen (HLA)-DQ/DR loci most predictive of susceptibility to type 1 diabetes (T1D). To assess the contribution of other MHC genes, in this exploratory analysis of Type 1 Diabetes Genetics Consortium (T1DGC) family data we characterize association between susceptibility and MHC single nucleotide polymorphism (SNP) genotype, with an emphasis on effects of genetic variation additional to carriage of predisposing or protective MHC haplotypes.