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Publication Information
Affiliation
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA. patcon@virginia.edu
Authors
Akolkar B, Chen WM, Concannon P, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rich SS, Todd JA, Type 1 Diabetes Genetics Consortium
Studies
Citation
Concannon P, Chen WM, Julier C, Morahan G, Akolkar B, Erlich HA, Hilner JE, Nerup J, Nierras C, Pociot F, Todd JA, Rich SS, Type 1 Diabetes Genetics Consortium. Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes 2009 Apr;58(4):1018-22. Epub 2009 Jan 9.Abstract
Type 1 diabetes arises from the actions of multiple genetic and environmental risk factors. Considerable success at identifying common genetic variants that contribute to type 1 diabetes risk has come from genetic association (primarily case-control) studies. However, such studies have limited power to detect genes containing multiple rare variants that contribute significantly to disease risk.