PubMed ID:
18802326
Public Release Type:
Journal
Publication Year: 2009
Affiliation: Rolf Luft Center for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden.
DOI:
https://doi.org/10.1159/000157627
Authors:
Bowden DW,
Brismar K,
Efendic S,
Flekac M,
Freedman BI,
Gu HF,
Hicks PJ,
Santos E,
Zhang D
Studies:
The Genetics of Kidneys in Diabetes
The TRPC1 gene on chromosome 3q22-24 resides within the linkage region for diabetic nephropathy (DN) in type 1 (T1D) and type 2 diabetes mellitus (T2D). A recent study has demonstrated that TRPC1 expression is reduced in the kidney of diabetic ZDF- and STZ-treated rats. The present study aimed to evaluate the genetic and functional role of TRPC1 in the development of DN.