NIDDK Central Repository - Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design.

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NIDDK Central Repository

Publication Information

DOI

10.1016/j.cct.2008.09.003

PubMed ID

18804555

Public Release Type

Journal

Publication Year

2009

Affiliation

Indiana University School of Medicine, Indianapolis, IN, United States.

Authors

Chalasani NP, Hoofnagle J, Kleiner DE, Kowdley KV, NASH CRN Research Group, Robuck PR, Sanyal AJ, Tonascia J, Unalp A

Studies

PIVENS

Citation

Chalasani NP, Sanyal AJ, Kowdley KV, Robuck PR, Hoofnagle J, Kleiner DE, Unalp A, Tonascia J, NASH CRN Research Group. Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design. Contemp Clin Trials 2009 Jan;30(1):88-96. Epub 2008 Sep 10.

Abstract

Non-alcoholic steatohepatitis (NASH) is a common liver disease associated with obesity and diabetes. NASH is a progressive disorder that can lead to cirrhosis and liver failure. Insulin resistance and oxidative stress are thought to play important roles in its pathogenesis. There is no definitive treatment for NASH.