PubMed ID:
18765632
Public Release Type:
Journal
Publication Year: 2008
Affiliation: Family Investigation of Nephropathy and Diabetes (FIND) Genetic Analysis and Data Coordinating Center, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
DOI:
https://doi.org/10.1167/iovs.07-1633
Authors:
Kimmel PL,
Kimmel PL,
Shah V,
Hanson RL,
Hanson RL,
Knowler WC,
Knowler WC,
Nelson RG,
Nelson RG,
Abboud H,
Abboud HE,
Abboud T,
Adler SG,
Arar N,
Arar NH,
Bobelu A,
Bowden DW,
Bowden DW,
Briggs JP,
Brooks G,
Budgett M,
Chakraborty GM,
Chakraborty R,
Chester J,
Chew EY,
Collins-Schramm HE,
Davis MD,
Duggirala R,
Duggirala R,
Elston RC,
Family Investigation of Nephropathy and Diabetes Research Group,
Fondran C,
Freedman BI,
Freedman BI,
Garcia C,
Getz-Fradley L,
Gonzalez J,
Goyes C,
Guo X,
Guo X,
Hanson R,
Hariri F,
Hernandez L,
Horvath A,
Humbert L,
Igo RP Jr,
Ingram-Drake L,
Ipp E,
Ipp E,
Iyengar SK,
Jenkinson C,
Jones L,
Juan R,
Jun G,
Kao L,
Kasinath BS,
Kessing B,
Klag M,
Kramp K,
LaPage J,
Li H,
Lovelace R,
Luethe C,
Meoni L,
Molineros J,
Nicholas SB,
O'Brien SJ,
Pahl M,
Pahl MV,
Parekh R,
Phillips LM,
Plaetke R,
Quade SR,
Quade SR,
Rasooly R,
Rasooly RS,
Rich SS,
Rotter J,
Rotter JI,
Saad MF,
Saad MF,
Sartorio V,
Satko SG,
Satko SG,
Scavini M,
Scavini M,
Schelling JR,
Sedor JR,
Seldin MF,
Sewemaenewa J,
Shah VO,
Sili I,
Slaughter M,
Smith MW,
Spainhour M,
Spielman R,
Stern M,
Taylor K,
Thompson M,
Viverette S,
Walker B,
Warren S,
Waseta B,
Whitehead T,
Winkler C,
Wolford J,
Young R,
Zager P,
Zager PG,
Zaletel E
Studies:
Family Investigation of Nephropathy and Diabetes
Diabetic retinopathy (DR) and diabetic nephropathy (DN) are serious microvascular complications of diabetes mellitus. Correlations between severity of DR and DN and computed heritability estimates for DR were determined in a large, multiethnic sample of diabetic families. The hypothesis was that (1) the severity of DR correlates with the presence and severity of nephropathy in individuals with diabetes mellitus, and (2) the severity of DR is under significant familial influence in members of multiplex diabetic families.