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Publication Information
Affiliation
Division of Transplant Surgery, University of Colorado, Aurora, CO 80262, USA.
Authors
Abecassis MM, Adult-to-Adult Living Donor Liver Transplantation Cohort Study Group, Al-Saden P, Armstrong DR, Artinian L, Ashworth A, Berg CL, Blei A, Blei AT, Brown RS Jr, Busuttil RW, Campsen J, Chawla T, Davis J, Emond JC, Everhart JE, Fair JH, Fenick E, Fisher RA, Freise CE, Garcia C, Ghobrial RM, Gillespie BW, Heese S, Hill-Callahan M, Hoofnagle JH, Howell T, Kam I, Kaminski M, Lok AS, Lowe M, MacLeod D, Merion RM, Nielsen CA, Odeh-Ramadan R, Ojo AO, Olthoff KM, Pruett TL, Robuck PR, Saab S, Seeff LB, Shaked A, Shaw M, Shearon TH, Shiffman ML, Terrault NA, Tong L, Trotter JF, Wisniewski KA
Studies
Citation
Campsen J, Blei AT, Emond JC, Everhart JE, Freise CE, Lok AS, Saab S, Wisniewski KA, Trotter JF, Adult-to-Adult Living Donor Liver Transplantation Cohort Study Group. Outcomes of living donor liver transplantation for acute liver failure: the adult-to-adult living donor liver transplantation cohort study. Liver Transpl 2008 Sep;14(9):1273-80.Abstract
For acute liver failure (ALF), living donor liver transplantation (LDLT) may reduce waiting time and provide better timing compared to deceased donor liver transplantation (DDLT). However, there are concerns that a partial graft would result in reduced survival of critically ill LDLT recipients and that the rapid evolution of ALF would lead to selection of inappropriate donors. We report outcomes for ALF patients (and their donors) evaluated for LDLT between 1998 and April 2007 from the Adult-to-Adult Living Donor Liver Transplantation Cohort. Of the 1201 potential LDLT recipients, 14 had ALF, only 6 of whom had an identified cause. The median time from listing to first donor evaluation was 1.5 days, and the median time from evaluation to transplantation was 1 day. One patient recovered without liver transplant, 3 of 10 LDLT recipients died, and 1 of 3 DDLT recipients died. Five of the 10 living donors had a total of 7 posttransplant complications. In conclusion, LDLT is rarely performed for ALF, but in selected patients it may be associated with acceptable recipient mortality and donor morbidity.