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PubMed ID:
18756453
Public Release Type:
Journal
Publication Year: 2008
Affiliation: Division of Transplant Surgery, University of Colorado, Aurora, CO 80262, USA.
DOI:
https://doi.org/10.1002/lt.21500
Authors:
Blei A,
Shaw M,
Trotter JF,
Kam I,
Garcia C,
Ghobrial RM,
Busuttil RW,
Artinian L,
Freise CE,
Terrault NA,
MacLeod D,
Merion RM,
Lok AS,
Ojo AO,
Gillespie BW,
Armstrong DR,
Hill-Callahan M,
Howell T,
Tong L,
Shearon TH,
Wisniewski KA,
Lowe M,
Fair JH,
Nielsen CA,
Berg CL,
Pruett TL,
Davis J,
Fisher RA,
Shiffman ML,
Fenick E,
Ashworth A,
Everhart JE,
Seeff LB,
Robuck PR,
Hoofnagle JH,
Campsen J,
Blei AT,
Emond JC,
Everhart JE,
Freise CE,
Lok AS,
Saab S,
Wisniewski KA,
Trotter JF,
Adult-to-Adult Living Donor Liver Transplantation Cohort Study Group,
Emond JC,
Brown RS Jr,
Odeh-Ramadan R,
Chawla T,
Heese S,
Abecassis MM,
Al-Saden P,
Shaked A,
Olthoff KM,
Kaminski M
Studies:
Adult Living Donor Liver Transplantation Studies
For acute liver failure (ALF), living donor liver transplantation (LDLT) may reduce waiting time and provide better timing compared to deceased donor liver transplantation (DDLT). However, there are concerns that a partial graft would result in reduced survival of critically ill LDLT recipients and that the rapid evolution of ALF would lead to selection of inappropriate donors. We report outcomes for ALF patients (and their donors) evaluated for LDLT between 1998 and April 2007 from the Adult-to-Adult Living Donor Liver Transplantation Cohort. Of the 1201 potential LDLT recipients, 14 had ALF, only 6 of whom had an identified cause. The median time from listing to first donor evaluation was 1.5 days, and the median time from evaluation to transplantation was 1 day. One patient recovered without liver transplant, 3 of 10 LDLT recipients died, and 1 of 3 DDLT recipients died. Five of the 10 living donors had a total of 7 posttransplant complications. In conclusion, LDLT is rarely performed for ALF, but in selected patients it may be associated with acceptable recipient mortality and donor morbidity.
