NIDDK Central Repository - A1C variability and the risk of microvascular complications in type 1 diabetes: data from the Diabetes Control and Complications Trial.

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NIDDK Central Repository

Publication Information

DOI

10.2337/dc08-0864

PubMed ID

18650371

Public Release Type

Journal

Publication Year

2008

Affiliation

Department of Clinical Biochemistry, Hull Royal Infirmary, Hull, UK. eric.kilpatrick@hey.nhs.uk

Authors

Atkin SL, Kilpatrick ES, Rigby AS

Studies

DCCT

Citation

Kilpatrick ES, Rigby AS, Atkin SL. A1C variability and the risk of microvascular complications in type 1 diabetes: data from the Diabetes Control and Complications Trial. Diabetes Care 2008 Nov;31(11):2198-202. Epub 2008 Jul 23.

Abstract

Debate remains as to whether short- or long-term glycemic instability confers a risk of microvascular complications in addition to that predicted by mean glycemia alone. In this study, we analyzed data from the Diabetes Control and Complications Trial (DCCT) to assess the effect of A1C variability on the risk of retinopathy and nephropathy in patients with type 1 diabetes.