NIDDK Central Repository - A single nucleotide polymorphism alters the sequence of SP1 binding site in the adiponectin promoter region and is associated with diabetic nephropathy among type 1 diabetic patients in the Genetics of Kidneys in Diabetes Study.

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NIDDK Central Repository

Publication Information

DOI

10.1016/j.jdiacomp.2008.05.004

PubMed ID

18599322

Public Release Type

Journal

Publication Year

2009

Affiliation

Department of Molecular Medicine and Surgery, Rolf Luft Center for Diabetes Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Authors

Brismar K, Efendic S, Gu HF, Ma J, Zhang D

Studies

GoKinD

Citation

Zhang D, Ma J, Brismar K, Efendic S, Gu HF. A single nucleotide polymorphism alters the sequence of SP1 binding site in the adiponectin promoter region and is associated with diabetic nephropathy among type 1 diabetic patients in the Genetics of Kidneys in Diabetes Study. J Diabetes Complications 2009 Jul-Aug;23(4):265-72. Epub 2008 Jul 3.

Abstract

The adiponectin promoter single nucleotide polymorphism (SNP) -11391G/A is found to be associated with nephropathy in type 1 diabetic (T1D) patients among Danish, but not French, Finnish, and Swedish populations. In the present study, we identified the binding sites for transcriptional factors in the adiponectin promoter region and also evaluated the association between adiponectin promoter polymorphisms and diabetic nephropathy (DN) in T1D patients.