NIDDK Central Repository - Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.

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NIDDK Central Repository

Publication Information

DOI

10.1186/1471-2350-9-47

PubMed ID

18505543

Public Release Type

Journal

Publication Year

2008

Affiliation

Rolf Luft Center for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. jun.ma@ki.se

Authors

Brismar K, Efendic S, Gu HF, Ma J, Zhang D

Studies

GoKinD

Citation

Ma J, Zhang D, Brismar K, Efendic S, Gu HF. Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population. BMC Med Genet 2008 May 27;9:47.

Abstract

The ICAM-1 gene is a strong positional and biological candidate for susceptibility to the development of T1D and DN. We have recently demonstrated that SNP rs5498(E469K) confers susceptibility to the development of T1D and might be associated with DN in Swedish Caucasians. The present study aimed to further evaluate the association between the ICAM-1 genetic polymorphisms and DN.