PubMed ID:
31171572
Public Release Type:
Journal
Publication Year: 2019
Affiliation: 1 Division of Cardiology, Department of Medicine, University of Michigan, Ann Arbor Michigan; 2
Department of
Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania; 3
Department of Medicine, Rush University Medical
Center, Chicago, Illinois; 4
Division of Nephrology, University of Heidelberg, Heidelberg, Germany; 5
Kidney Institute,
University of Kansas Medical Center, Kansas City, Kansas; 6
Division of Nephrology, Mayo Clinic, Rochester,
Minnesota; and 7
Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland
DOI:
https://doi.org/10.1681/ASN.2018121227
Authors:
Landsittel DP,
Yu ASL,
Wei C,
Zeier M,
Torres VE,
Roth S,
Pao CS,
Hayek SS,
Reiser J
Request IDs:
21643
Studies:
Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease
Background Levels of soluble urokinase plasminogen activator receptor (suPAR), an inflammation marker, are strongly predictive of incident kidney disease. Patients with autosomal dominant polycystic kidney disease (ADPKD) experience progressive decline in renal function, but rates of decline and outcomes vary greatly. Whether suPAR levels are predictive of declining kidney function in patients with ADPKD is unknown. Methods We assessed suPAR levels in 649 patients with ADPKD who underwent scheduled follow-up for at least 3 years, with repeated measurements of height-adjusted total kidney volume and creatininederived eGFR. We used linear mixed models for repeated measures and Cox proportional hazards to characterize associations between baseline suPAR levels and follow-up eGFR or incident ESRD. Results The median suPAR level was 2.47 ng/ml and median height-adjusted total kidney volume was 778, whereas mean eGFR was 84 ml/min per 1.73 m2 . suPAR levels were associated with height-adjusted total kidney volume (b=0.02; 95% confidence interval, 0.01 to 0.03), independent of age, sex, race, hypertension, and eGFR. Patients in the lowest suPAR tertile (,2.18 ng/ml) had a 6.8% decline in eGFR at 3 years and 22% developed CKD stage 3, whereas those in the highest tertile (suPAR.2.83 ng/ml) had a 19.4% decline in eGFR at 3 years and 68% developed CKD stage 3. suPAR levels .2.82 ng/ml had a 3.38-fold increase in the risk of incident ESRD. Conclusions suPAR levels were associated with progressive decline in renal function and incident ESRD in patients with ADPKD, and may aid early identification of patients at high risk of disease progression.