PubMed ID:
18252895
Public Release Type:
Journal
Publication Year: 2008
Affiliation: Roche Molecular Systems, 1145 Atlantic Ave., Alameda, CA 94501, USA. Henry.Erlich@Roche.com
DOI:
https://doi.org/10.2337/db07-1331
Authors:
Bonella P,
Carlson JA,
Concannon P,
Erlich H,
Fear AL,
Lavant E,
Louey A,
Moonsamy P,
Mychaleckyj JC,
Noble J,
Todd JA,
Type 1 Diabetes Genetics Consortium,
Valdes AM,
Varney M
Studies:
Type 1 Diabetes Genetics Consortium
The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes.