NIDDK Central Repository - HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families.

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NIDDK Central Repository

Publication Information

DOI

10.2337/db07-1331

PubMed ID

18252895

Public Release Type

Journal

Publication Year

2008

Affiliation

Roche Molecular Systems, 1145 Atlantic Ave., Alameda, CA 94501, USA. Henry.Erlich@Roche.com

Authors

Bonella P, Carlson JA, Concannon P, Erlich H, Fear AL, Lavant E, Louey A, Moonsamy P, Mychaleckyj JC, Noble J, Todd JA, Type 1 Diabetes Genetics Consortium, Valdes AM, Varney M

Studies

T1DGC

Citation

Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P, Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008 Apr;57(4):1084-92. Epub 2008 Feb 5.

Abstract

The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes.