NIDDK Central Repository - Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial--revisited.

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NIDDK Central Repository

Publication Information

DOI

10.2337/db07-1618

PubMed ID

18223010

Public Release Type

Journal

Publication Year

2008

Affiliation

The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA. jml@biostat.bsc.gwu.edu

Authors

DCCT/EDIC Research Group, Genuth S, Lachin JM, Nathan DM, Rutledge BN, Zinman B

Studies

DCCT

Citation

Lachin JM, Genuth S, Nathan DM, Zinman B, Rutledge BN, DCCT/EDIC Research Group. Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial--revisited. Diabetes 2008 Apr;57(4):995-1001. Epub 2008 Jan 25.

Abstract

The Diabetes Control and Complications Trial (Diabetes 44:968-983, 1995) presented statistical models suggesting that subjects with similar A1C levels had a higher risk of retinopathy progression in the conventional treatment group than in the intensive treatment group. That analysis has been cited to support the hypothesis that specific patterns of glucose variation, in particular postprandial hyperglycemia, contribute uniquely to an increased risk of microvascular complications above and beyond that explained by the A1C level.