PubMed ID:
18223010
Public Release Type:
Journal
Publication Year: 2008
Affiliation: The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA. jml@biostat.bsc.gwu.edu
DOI:
https://doi.org/10.2337/db07-1618
Authors:
DCCT/EDIC Research Group,
Genuth S,
Lachin JM,
Nathan DM,
Rutledge BN,
Zinman B
Studies:
Diabetes Control and Complications Trial
The Diabetes Control and Complications Trial (Diabetes 44:968-983, 1995) presented statistical models suggesting that subjects with similar A1C levels had a higher risk of retinopathy progression in the conventional treatment group than in the intensive treatment group. That analysis has been cited to support the hypothesis that specific patterns of glucose variation, in particular postprandial hyperglycemia, contribute uniquely to an increased risk of microvascular complications above and beyond that explained by the A1C level.