PubMed ID:
18200657
Public Release Type:
Journal
Publication Year: 2008
Affiliation: Inflammatory Bowel Disease Center, Yale University, 300 Cedar Street, New Haven, CT 06519, USA. judy.cho@yale.edu
DOI:
https://doi.org/10.3748/wjg.14.338
Authors:
Cho JH
Studies:
Inflammatory Bowel Disease Genetics
Genome-wide association studies have firmly established that many genomic loci contribute to inflammatory bowel disease, especially in Crohn's disease. These studies have newly-established the importance of the interleukin 23 and autophagy pathways in disease pathogenesis. Future challenges include: (1) the establishment of precisely causal alleles, (2) definition of altered functional outcomes of associated and causal alleles and (3) integration of genetic findings with environmental factors.