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PubMed ID:
18065518
Public Release Type:
Journal
Publication Year: 2008
Affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045-6511, USA.
DOI:
https://doi.org/10.2337/db07-0900
Authors:
Jahromi MM,
Aly TA,
Eisenbarth GS,
Rewers MJ,
Fain PR,
Erlich HA,
Kretowski A,
Fingerlin TE,
Babu SR,
Fernando MS,
Baschal EE
Studies:
Type 1 Diabetes Genetics Consortium
HLA-DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 (DR3/4-DQ8) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. Our goal was to search for non-DR/DQ MHC genetic determinants that cause the additional risk in the DR3/4-DQ8 siblings who share both MHC haplotypes.
