NIDDK Central Repository - Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex.

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NIDDK Central Repository

Publication Information

DOI

10.2337/db07-0900

PubMed ID

18065518

Public Release Type

Journal

Publication Year

2008

Affiliation

Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045-6511, USA.

Authors

Aly TA, Babu SR, Baschal EE, Eisenbarth GS, Erlich HA, Fain PR, Fernando MS, Fingerlin TE, Jahromi MM, Kretowski A, Rewers MJ

Studies

T1DGC

Citation

Aly TA, Baschal EE, Jahromi MM, Fernando MS, Babu SR, Fingerlin TE, Kretowski A, Erlich HA, Fain PR, Rewers MJ, Eisenbarth GS. Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex. Diabetes 2008 Mar;57(3):770-6. Epub 2007 Dec 7.

Abstract

HLA-DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 (DR3/4-DQ8) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. Our goal was to search for non-DR/DQ MHC genetic determinants that cause the additional risk in the DR3/4-DQ8 siblings who share both MHC haplotypes.