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Publication Information
Affiliation
Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F-24, Atlanta, GA 30341, USA. snc4@cdc.gov
Authors
Anderson KL, Cleary PA, Cordovado SK, Gong H, Hancock LN, Hendrix MM, Mueller PW, Warram JH, Zhao Y
Studies
Citation
Cordovado SK, Zhao Y, Warram JH, Gong H, Anderson KL, Hendrix MM, Hancock LN, Cleary PA, Mueller PW. Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study. Diabetes 2008 Feb;57(2):518-22. Epub 2007 Nov 26.Abstract
The purpose of this study was to examine whether known genetic risk factors for type 1 diabetes (HLA-DRB1, -DQA1, and -DQB1 and insulin locus) play a role in the etiology of diabetic nephropathy. RESEARCH DESIGN AND METHODS; Genetic analysis of HLA-DRB1, -DQA1, -DQB1 and the insulin gene (INS) was performed in the Genetics of Kidneys in Diabetes (GoKinD) collection of DNA (European ancestry subset), which includes case patients with type 1 diabetes and nephropathy (n = 829) and control patients with type 1 diabetes but not nephropathy (n = 904). The availability of phenotypic and genotypic data on GoKinD participants allowed a detailed analysis of the association of these genes with diabetic nephropathy.