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PubMed ID:
18039812
Public Release Type:
Journal
Publication Year: 2008
Affiliation: Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F-24, Atlanta, GA 30341, USA. snc4@cdc.gov
DOI:
https://doi.org/10.2337/db07-0826
Authors:
Cleary PA,
Hancock LN,
Hendrix MM,
Anderson KL,
Gong H,
Warram JH,
Zhao Y,
Cordovado SK,
Mueller PW
Studies:
The Genetics of Kidneys in Diabetes
The purpose of this study was to examine whether known genetic risk factors for type 1 diabetes (HLA-DRB1, -DQA1, and -DQB1 and insulin locus) play a role in the etiology of diabetic nephropathy. RESEARCH DESIGN AND METHODS; Genetic analysis of HLA-DRB1, -DQA1, -DQB1 and the insulin gene (INS) was performed in the Genetics of Kidneys in Diabetes (GoKinD) collection of DNA (European ancestry subset), which includes case patients with type 1 diabetes and nephropathy (n = 829) and control patients with type 1 diabetes but not nephropathy (n = 904). The availability of phenotypic and genotypic data on GoKinD participants allowed a detailed analysis of the association of these genes with diabetic nephropathy.
