PubMed ID:
18003762
Public Release Type:
Journal
Publication Year: 2008
Affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, Rm. 1300, 10900 Euclid Ave., Cleveland, OH 44106-7281, USA.
DOI:
https://doi.org/10.2337/db07-0313
Authors:
Kimmel PL,
Hanson RL,
Knowler WC,
Nelson RG,
Abboud HE,
Adler SG,
Arar NH,
Bowden DW,
Elston RC,
Family Investigation of Nephropathy and Diabetes Research Group,
Freedman BI,
Goddard KA,
Guo X,
Ipp E,
Iyengar SK,
Jun G,
Kao WH,
Kasinath BS,
Klag MJ,
Nicholas SB,
Pahl MV,
Parekh RS,
Quade SR,
Rich SS,
Saad MF,
Scavini M,
Schelling JR,
Sedor JR,
Shah VO,
Smith MW,
Taylor K,
Winkler CA,
Zager PG
Studies:
Family Investigation of Nephropathy and Diabetes
Diabetic nephropathy, the most common cause of end-stage renal disease, aggregates in families and specific ethnic groups. Deconstructing diabetic nephropathy into intermediate, quantitative phenotypes may increase feasibility of detecting susceptibility loci by genetic screens. Glomerular filtration rate (GFR), which characterizes diabetic nephropathy, was employed as a quantitative trait in a preliminary whole-genome scan.