NIDDK Central Repository - Distribution of neuropeptide Y Leu7Pro polymorphism in patients with type 1 diabetes and diabetic nephropathy among Swedish and American populations.

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NIDDK Central Repository

Publication Information

DOI

10.1530/EJE-07-0354

PubMed ID

17984244

Public Release Type

Journal

Publication Year

2007

Affiliation

Department of Molecular Medicine and Surgery, L6:B2, Karolinska Institutet, Rolf Luft Center for Diabetes Research, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

Authors

Brismar K, Dahlquist G, Efendic S, Falhammar H, Gu HF, Ma J, Möllsten A, Nordman S

Studies

GoKinD

Citation

Ma J, Nordman S, Möllsten A, Falhammar H, Brismar K, Dahlquist G, Efendic S, Gu HF. Distribution of neuropeptide Y Leu7Pro polymorphism in patients with type 1 diabetes and diabetic nephropathy among Swedish and American populations. Eur J Endocrinol 2007 Nov;157(5):641-5.

Abstract

The distribution of Leu7Pro polymorphism in the neuropeptide Y gene shows a geographical north to south gradient of decreasing frequency, suggesting that it may be a population-specific causal variant. This polymorphism is found to be associated with diabetic nephropathy (DN) and coronary heart disease in Finnish women with type 1 diabetes (T1D). The present study aims to evaluate the susceptibility of this polymorphism to the development of DN in two different populations.