PubMed ID:
17984244
Public Release Type:
Journal
Publication Year: 2007
Affiliation: Department of Molecular Medicine and Surgery, L6:B2, Karolinska Institutet, Rolf Luft Center for Diabetes Research, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
DOI:
https://doi.org/10.1530/EJE-07-0354
Authors:
Brismar K,
Dahlquist G,
Efendic S,
Falhammar H,
Gu HF,
Ma J,
Möllsten A,
Nordman S
Studies:
The Genetics of Kidneys in Diabetes
The distribution of Leu7Pro polymorphism in the neuropeptide Y gene shows a geographical north to south gradient of decreasing frequency, suggesting that it may be a population-specific causal variant. This polymorphism is found to be associated with diabetic nephropathy (DN) and coronary heart disease in Finnish women with type 1 diabetes (T1D). The present study aims to evaluate the susceptibility of this polymorphism to the development of DN in two different populations.